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New advances in CRISPR/Cas9 delivery

Submission deadline: 30 November 2023
Special Issue Editors
Alessandro Parodi
Sirius University of Science and Technology, Russian Federation
Interests: Nanomedicine; Immune metabolism; Cancer; Sepsis; Pulmonary biology
Special Issue Information

The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system is the most advanced tool for genome manipulation, paving the way for significant breakthroughs in every field of life science and medicine. However, its effectiveness depends on its proper delivery in the cell cytoplasm. For this reason, numerous technologies and approaches were tested for achieving safe, precise and effective gene editing. Viral vectors, nanocarriers and physical methods are only some technologies currently extensively investigated for this purpose. While some delivery approaches  showed great potential in vitro and ex-vivo, many efforts are focused on generating CRISPR/Cas9 therapeutics for in vivo applications.

In this special issue, we want to focus the attention on the several efforts performed to improve the delivery of CRISPR/Cas9 in order to highlight pros and cons of different technologies as a function of their application.

medical nanotechnology
delivery systems
nano drug delivery
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Gene & Protein in Disease, Electronic ISSN: 2811-003X Print ISSN: TBA, Published by AccScience Publishing