Acute Promyelocytic Leukemia Diagnosed at the End of First Trimester with a Successful Outcome

© 2018 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC-by the license) ( https://creativecommons.org/licenses/by-nc/4.0/ )

Download PDF

Cite

XML

Abstract

The treatment and management of patients with acute promyelocytic leukemia (APL) diagnosed in pregnancy can involve a wide range of difficulties and limitations. Thus, these cases are each unique and present challenges to physicians. The aim of this study was to present the case of a 24-year-old patient who was diagnosed with APL in the 14th week of pregnancy who was treated successfully with all-trans retinoic acid and chemotherapy.

Keywords

Acute promyelocytic leukemia

disseminated intravascular coagulation

hemorrhagic diathesis

pregnancy

remission induction chemotherapy

Conflict of interest

The authors declared that no conflict of interest.

References

1. Sanz MA, Grimwade D, Tallman MS, Lowenberg B, Fenaux P, Estey EH, et al. Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet. Blood 2009;113:1875–91. [CrossRef]
2. Tallman MS, Altman JK. How I treat acute promyelocytic leukemia. Blood 2009;114:5126–35. [CrossRef]
3. Fracchiolla NS, Sciumè M, Dambrosi F, Guidotti F, Ossola MW, Chidini G, et al. Acute myeloid leukemia and pregnancy: clinical experience from a single center and a review of the literature. BMC Cancer 2017;17:442. [CrossRef]
4. Sanz MA, Montesinos P, Casale MF, Díaz-Mediavilla J, Jiménez S, Fernández I, et al. Maternal and fetal outcomes in pregnant women with acute promyelocytic leukemia. Ann Hematol 2015;94:1357–61. [CrossRef]
5. Valappil S, Kurkar M, Howell R. Outcome of pregnancy in women treated with all-trans retinoic acid; a case report and review of literature. Hematology 2007;12:415–8. [CrossRef]
6. Agarwal K, Patel M, Agarwal V. A Complicated Case of Acute Promyelocytic Leukemia in the Second Trimester of Pregnancy Successfully Treated with All-trans-Retinoic Acid. Case Rep Hematol 2015;2015:634252. [CrossRef]
7. Maruyama S, Sato Y, Moriuchi K, Kanbayashi S, Ri Y, Taga A, et al. Fetal death following idarubicin treatment for acute promyelocytic leukemia in pregnancy-A case report. Eur J Obstet Gynecol Reprod Biol 2017;218:140. [CrossRef]
8. Verma V, Giri S, Manandhar S, Pathak R, Bhatt VR. Acute promyelocytic leukemia during pregnancy: a systematic analysis of outcome. Leuk Lymphoma 2016;57:616–22. [CrossRef]
9. Lo-Coco F, Cicconi L, Breccia M. Current standard treatment of adult acute promyelocytic leukaemia. Br J Haematol 2016;172:841–54. [CrossRef]
10. Ali S, Jones GL, Culligan DJ, Marsden PJ, Russell N, Embleton ND, et al.; British Committee for Standards in Haematology. Guidelines for the diagnosis and management of acute myeloid leukaemia in pregnancy. Br J Haematol 2015;170:487–95.
11. Aoki A, Yoneda N, Yoneda S, Miyazono T, Sugiyama T, Saito S. Massive postpartum hemorrhage after chemotherapy in a patient with acute promyelocytic leukemia. J Obstet Gynaecol Res 2011;37:1759–63. [CrossRef]

Previous article in this issue

Next article in this issue

Eurasian Journal of Medicine and Oncology, Electronic ISSN: 2587-196X Print ISSN: 2587-2400, Published by AccScience Publishing