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MINI-REVIEW

Innovative approaches and challenges in antibody-based therapeutics for Alzheimer’s disease

Tolulope Judah Gbayisomore1,2* ,  Kingsley Afoke Iteire2 ,  Inibehe Ime Okon3 ,  Isunu Lucky Efe4 ,  Okikiola Oyindamola Falua5 ,  Waliullahi Odebode Opeyemi1 ,  Alex Sorlelodum Gideon6 ,  Rufus Oluwagbemileke Ajayi7 ,  Abdul-Hanan Saani Inusah8
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1 Data Intelligence and Scientific Innovation Unit, University of Benin Teaching Hospital, Benin City, Edo State, Nigeria
2 Department of Anatomy, Faculty of Basic Medical Sciences, University of Medical Sciences, Ondo City, Ondo State, Nigeria
3 Department of Research, Medical Research Circle (MedReC), Bukavu, South Kivu, Democratic Republic of the Congo
4 Department of Microbiology, Faculty of Sciences, Federal University of Technology, Akure, Ondo State, Nigeria
5 Department of Biochemistry, Faculty of Basic medical sciences, Olabisi Onabanjo University, Ago-Iwoye, Ogun State, Nigeria
6 Department of Anatomy, University of Port Harcourt, Port Harcourt, Rivers State, Nigeria
7 Department of Public Health, University of Illinois Springfield, Illinois, United states of America
8 Department of Public Health, School of Medicine, University for Development Studies, Tamale, Ghana
INNOSC Theranostics and Pharmacological Sciences, 2953 https://doi.org/10.36922/itps.2953
Submitted: 16 February 2024 | Accepted: 28 March 2024 | Published: 30 April 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution -Noncommercial 4.0 International License (CC BY-NC 4.0) ( https://creativecommons.org/licenses/by-nc/4.0/ )
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Abstract

Neurological conditions, such as Alzheimer’s disease (AD) and tau-related pathologies, represent a substantial worldwide health dilemma. This review explores recent advancements and challenges in single-domain antibody (VHH)-based strategies targeting beta-secretase 1 (BACE1) inhibition and tau-related therapeutics. The methodology adopted in this study involved a comprehensive search of databases (e.g., Scopus, PubMed, and Google Scholar), with recent articles cited to provide an up-to-date overview. The research examines the limitations of current AD treatments, emphasizing the need for innovative techniques. We, further, discuss potential gene transfer methods using adeno-associated virus-based vectors for central nervous system delivery of single-domain immunoglobins/antibodies (VHHs) to inhibit BACE1. In addition, insights into anti-tau therapeutics, including passive immunization and active vaccines, offer novel insights into research. These findings hold implications for the redesign of therapies for neurodegenerative disorders and the advancement of clinical understanding.

Keywords
Neurological condition
Single-domain antibodies
BACE1 inhibition
Tau-related therapeutics
Funding
None.
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Conflict of interest
The authors declare that they have no competing interests.
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INNOSC Theranostics and Pharmacological Sciences, Electronic ISSN: 2705-0823 Published by AccScience Publishing
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